Cough symptom severity in patients with refractory or unexplained chronic cough: a systematic survey and conceptual framework

Background Cough severity represents an important subjective endpoint in assessing the effectiveness of therapies for patients with chronic cough.Although cough-specific quality of life questionnaires exist, a widely available cough severity instrument with established measurement properties remains unavailable.Aims To identify and summarise Hoover

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Opa1 relies on cristae preservation and ATP synthase to curtail reactive oxygen species accumulation in mitochondria

Reactive oxygen species (ROS) are a common product of active mitochondrial respiration carried in mitochondrial cristae, but whether cristae shape influences Suitcases ROS levels is unclear.Here we report that the mitochondrial fusion and cristae shape protein Opa1 requires mitochondrial ATP synthase oligomers to reduce ROS accumulation.In cells fu

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A review of the botany, metabolites, pharmacology, toxicity, industrial applications, and processing of Polygalae Radix: the “key medicine for nourishing life”

Polygalae radix (PR) is the dried root of Polygala tenuifolia Willd.and Polygala sibirica L.and enjoys the reputation as the “key medicine for nourishing life.” In this study, information about “Polygala tenuifolia Willd.,” “Polygala sibirica L.,” and “Yuanzhi” was retrieved from scientific databases, including Google Scholar, Baidu

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